Table 1.
Transcripts of interest differentially expressed in X-LAG versus normal pituitary
| Gene symbol | Description | log2 Fold change | p value | p adjusted |
|---|---|---|---|---|
| GPR101 | G protein-coupled receptor 101 | 12.63436884 | 1.29E−07 | 0.000190613 |
| CBLN1 | cerebellin 1 precursor | 5.512119335 | 0.000563223 | 0.069604995 |
| THBS2 | thrombospondin 2 | 5.308143562 | 2.21E−05 | 0.006548969 |
| SHC3 | SHC adaptor protein 3 | 3.511547641 | 1.30E−05 | 0.006548969 |
| HEPACAM2 | HEPACAM family member 2 | 3.438855732 | 0.001902735 | 0.100777001 |
| ECEL1 | endothelin converting enzyme like 1 | 3.435679699 | 0.000217119 | 0.04024841 |
| OTOS | otospiralin | 3.02397859 | 0.001895077 | 0.100777001 |
| ROBO2 | roundabout guidance receptor 2 | 2.710070311 | 0.001458344 | 0.090601717 |
| PDE3A | phosphodiesterase 3A | 2.661730163 | 1.97E−05 | 0.006548969 |
| FKBP10 | FKBP prolyl isomerase 10 | 2.293691778 | 0.000235806 | 0.041141147 |
| RAB27B | RAB27B, member RAS oncogene family | 2.273319657 | 0.000154602 | 0.035272955 |
| ZNF185 | zinc finger protein 185 with LIM domain | 2.272444372 | 0.00077183 | 0.078939629 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | 2.215979663 | 0.000302407 | 0.049829942 |
| RCN1 | reticulocalbin 1 | 1.79981704 | 0.001001391 | 0.08735662 |
| THY1 | Thy-1 cell surface antigen | 1.693370111 | 0.003678918 | 0.132060483 |
| FAM163A | family with sequence similarity 163 member A | 1.58328952 | 0.015330845 | 0.231996364 |
| MEF2C | myocyte enhancer factor 2C | 1.295394391 | 0.005879336 | 0.169266482 |
| CNTN2 | contactin 2 | 1.257122224 | 0.008331689 | 0.191799297 |
| ACSL6 | acyl-CoA synthetase long chain family member 6 | 1.193527525 | 0.058994577 | 0.356575463 |
| NRXN3 | neurexin 3 | 1.118119659 | 0.003173021 | 0.132060483 |
| ZNF667 | zinc finger protein 667 | 1.085357541 | 0.000197451 | 0.039042708 |
| PTPRK | protein tyrosine phosphatase receptor type K | 1.060081218 | 0.003335589 | 0.132060483 |
| CDH18 | cadherin 18 | 1.035159724 | 0.002714759 | 0.125756193 |
| NCALD | neurocalcin delta | 1.021986775 | 0.025977855 | 0.281559841 |
| AFAP1 | actin filament associated protein 1 | 0.879150352 | 0.004961622 | 0.151713106 |
| JMY | junction mediating and regulatory protein, p53 cofactor | −0.697771242 | 0.00521534 | 0.156249487 |
| IPO7 | importin 7 | −0.703833909 | 0.006282581 | 0.169612007 |
| DENND4A | DENN domain containing 4A | −0.820624498 | 0.00709545 | 0.179872693 |
| ARHGAP26 | Rho GTPase activating protein 26 | −0.858268895 | 0.00593517 | 0.169266482 |
| HTRA1 | HtrA serine peptidase 1 | −0.933790787 | 0.042763447 | 0.326057545 |
| CHD3 | chromodomain helicase DNA binding protein 3 | −0.972833851 | 0.011306594 | 0.224110606 |
| ENAH | ENAH actin regulator | −1.006496792 | 0.000133954 | 0.033108953 |
| PTPRS | protein tyrosine phosphatase receptor type S | −1.078053314 | 0.001090912 | 0.089879005 |
| SYNE2 | spectrin repeat containing nuclear envelope protein 2 | −1.252332472 | 0.001496792 | 0.090601717 |
| ST18 | ST18 C2H2C-type zinc finger transcription factor | −1.257373855 | 0.006370766 | 0.169612007 |
| SLC5A3 | solute carrier family 5 member 3 | −1.27293174 | 0.043192658 | 0.326809756 |
| IGFBP5 | insulin like growth factor binding protein 5 | −1.470642696 | 0.00204994 | 0.104829669 |
| MCOLN3 | mucolipin TRP cation channel 3 | −1.538158909 | 0.008341911 | 0.191799297 |
| A2M | alpha-2-macroglobulin | −1.546266649 | 0.00460635 | 0.148504708 |
| ANXA1 | annexin A1 | −1.554518488 | 0.047250273 | 0.336077478 |
| RAB3B | RAB3B, member RAS oncogene family | −1.559168136 | 0.000489003 | 0.067755285 |
| CACNA1H | calcium voltage-gated channel subunit alpha1 H | −1.615245675 | 0.000484715 | 0.067755285 |
| STEAP4 | STEAP4 metalloreductase | −1.615302685 | 7.62E−05 | 0.020556875 |
| FBXO32 | F-box protein 32 | −1.626663872 | 0.001474508 | 0.090601717 |
| DSP | desmoplakin | −1.805180049 | 8.06E−06 | 0.005978382 |
| SOD2 | superoxide dismutase 2 | −1.853240635 | 0.042101935 | 0.323536447 |
| TGFBR3 | transforming growth factor beta receptor 3 | −1.874227585 | 1.58E−05 | 0.006548969 |
| OBSCN | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | −2.04135558 | 0.000920676 | 0.085335122 |
| SORBS1 | sorbin and SH3 domain containing 1 | −2.100457177 | 0.010402284 | 0.220975104 |
| AEBP1 | AE binding protein 1 | −2.318738851 | 0.010430383 | 0.220975104 |
| COL6A6 | collagen type VI alpha 6 chain | −2.618856526 | 0.012027287 | 0.224358063 |
| GPC4 | glypican 4 | −3.013712734 | 0.000545355 | 0.069604995 |
| NPTX2 | neuronal pentraxin 2 | −4.197420142 | 2.05E−05 | 0.006548969 |
| POMC | proopiomelanocortin | −4.876589807 | 3.01E−07 | 0.000297977 |
| LHB | luteinizing hormone subunit beta | −8.869100817 | 4.10E−09 | 1.22E−05 |
55 differentially regulated genes (p value < 0.05) were identified by both analytical methods (edgeR/limma and DESeq2) that were employed to analyze the RNA-seq data. The transcripts are sorted by log2 fold change. EdgeR/limma-derived values are presented in the table.