Table 3.
Uni- and multi-variable analysis of the most relevant demographics and clinical–pathological factors according to RFS (recurrence-free survival) and CFS (carcinoma-free survival).
| Variable | Recurrence-Free Survival | |||||
|---|---|---|---|---|---|---|
| 5-year RFS (95% CI) | Cox proportional-hazard model | |||||
| Univariable analysis | Multivariable analysis | |||||
| HR (95% CI) | p-value | HR (95% CI) | p-value | |||
| Sex | Male | 74.3% (61.0–90.6%) | Reference | 0.018 | Reference | 0.044 |
| Female | 48.2% (34.5–67.6%) | 2.24 (1.15–4.38) | 2.07 (1.02–4.20) | |||
| Age at diagnosis, years | <65 | 64.2% (50.5–81.6%) | Reference | 0.403 | Reference | 0.889 |
| ≥65 | 57.0% (42.4–76.7%) | 1.31 (0.69–2.49) | 1.05 (0.52–2.12) | |||
| Previous oral carcinoma | No | 68.3% (56.5–82.5%) | Reference | 0.005 | Reference | 0.009 |
| Yes | 44.3% (27.7–70.6%) | 2.60 (1.33–5.07) | 2.54 (1.26–5.13) | |||
| Site of origin | Tongue | 62.6% (48.4–80.9%) | Reference | 0.584 | Reference | 0.498 |
| Other subsites | 59.5% (44.8–79.1%) | 1.20 (0.62–2.33) | 1.26 (0.65–2.45) | |||
| Grade of dysplasia | SIN1-2 | 63.9% (51.9–78.7%) | Reference | 0.121 | Reference | 0.554 |
| SIN3/CIS | 52.8% (35.7–78.1%) | 1.70 (0.87–3.32) | 1.25 (0.60–2.62) | |||
| Margins of resection | Free | 62.1% (48.8–78.9%) | Reference | 0.219 | Reference | 0.360 |
| Involved by dysplasia | 60.4% (45.8–79.6%) | 1.50 (0.78–2.88) | 1.37 (0.70–2.68) | |||
CI, confidence interval; CIS, carcinoma in situ; HR, hazard ratio; SIN, squamous intraepithelial neoplasia. The bold values are the statistically significant ones.