. 2022 Apr 21;12:886404. doi: 10.3389/fonc.2022.886404

Table 4.

Uni- and multi-variable analysis of the most relevant demographics and clinical–pathological factors according to CFS (carcinoma-free survival).

Variable		Carcinoma-Free Survival					Carcinoma-Free Survival (patients without previous OSCC)
		5-year RFS (95% CI)	Cox proportional-hazard model					Cox proportional-hazard model
			Univariable analysis		Multivariable analysis		5-year RFS (95% CI)	Univariable analysis
			HR (95% CI)	p-value	HR (95% CI)	p-value		HR (95% CI)	p-value
Sex	Male	88.0% (78.4–98.7%)	Reference	0.085	Reference	0.098	97.1% (91.5–100%)	Reference	0.063
	Female	65.0% (51.1–82.6%)	2.10 (0.90–4.8)	0.085	2.05 (0.87–4.81)	0.098	68.3% (52.7–88.5%)	3.39 (0.93–12.3)	0.063
Age at diagnosis - years	<65	85.8% (75.6–97.3%)	Reference	0.136			90.1% (79.8–100%)	Reference	0.163
	≥65	65.3% (50.8–83.8%)	1.85 (0.82–4.14)	0.136			73.2% (57.5–93.3%)	2.19 (0.73–6.62)	0.163
Previous oral carcinoma	No	81.9% (72.1–93.2%)	Reference	0.019	Reference	0.019
	Yes	60.6% (41.7–88.1%)	2.65 (1.18–5.96)	0.019	2.73 (1.18–6.31)	0.019
Site of origin	Tongue	79.5% (67.6–93.4%)	Reference	0.663			92.6% (83.2–100%)	Reference	0.066
	Other subsites	70.6% (56.5–88.2%)	1.20 (0.52–2.78)	0.663			70.7% (54.5–91.7%)	4.25 (0.91–19.87)	0.066
Grade of dysplasia	SIN1-2	79.4% (68.8–91.6%)	Reference	0.077	Reference	0.175	81.3% (69.9–94.4%)	Reference	0.758
	SIN3/CIS	66.5% (49.9–88.7%)	2.11 (0.92–4.84)	0.077	1.79 (0.77–4.16)	0.175	83.3% (64.7–100%)	1.22 (0.34–4.47)	0.758
Margins of resection	Free	75.4% (63.4–89.2%)	Reference	0.479			82.9% (71.0–96.8%)	Reference	0.498
	Involved by dysplasia	78.1% (64.7–94.3%)	1.36 (0.58–3.15)	0.479			81.4% (66.3–100%)	1.51 (0.46–4.99)	0.498

CI, confidence interval; CIS, carcinoma in situ; HR, hazard ratio; SIN, squamous intraepithelial neoplasia. The bold values are the statistically significant ones.