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Immunohistochemistry of serial chase of BrdU-positive cells in ESS grafted to athymic mice. BrdU pulses were performed on postoperative days 17–19. Chase days were: (A) 20, (B) 27, (C) 34, (D) 48. The time course shows a progressive decrease of label-retaining cells (brown stain) in the basal epidermis, with migration through the epidermal strata to loss by desquamation. Scale bar = 0.1 mm.
