TABLE 1.
Inhibition of influenza virus replication by test compoundsa
| Compound | A/Victoria/3/75 (H3N2)
|
B/Hong Kong/5/72
|
||
|---|---|---|---|---|
| EC50 | TC25 | EC50 | TC25 | |
| 4 | 2.0 ± 1.8 | >1,000 | 305 ± 15 | >1,000 |
| 1 | 48 ± 26 | >3,200 | 650 ± 320 | >3,200 |
| Ribavirin | 5.9 ± 2.7 | >130 | 6.3 ± 3.6 | >130 |
a
EC50, the concentration (μM) of compound that reduced virus-induced cytopathogenic effects by 50% in MDCK cells. Values are means ± standard deviations of triplicate measurements. TC25, the concentration (μM) of compound that resulted in the death of 25% of the MDCK cells.