Table 1.

In vitro binding properties of the indole-based ligands^a.

Compd.	Ki (σ1) (nmol/L)	Ki (σ2) (nmol/L)	Ki (σ1)/Ki (σ2)
2	149 ± 67	6.30 ± 2.00c	24
3	190 ± 97	8.91 ± 1.40	21
4	70 ± 14	9.46 ± 1.20c	7
5	259 ± 23	7.73 ± 4.49c	33
6	450 ± 89	4.40 ± 1.43c	102
7	357 ± 94	8.68 ± 1.99	41
8b	1698 ± 548	2.40 ± 0.58	708
9b	371 ± 105	1.79 ± 0.86	207
10b	187 ± 1.41	3.27 ± 0.19	57
11b	376 ± 351	2.63 ± 0.48	143

^aValues are the means ± standard deviation (SD) of at least two independent experiments, each done in triplicate.

^bFrom Ref. 29.

^cn = 2.