Fig. 4. Results from the inhibition of Gal-3 in an ELISA-inspired assay. (a) Exemplary inhibition curves of the inhibition with structures 4, 8, 9, 10, 11 and negative control 16. Values are normalized to the signal of pure Gal-3. (b–d) IC50 values [μM] (black) and RIP (grey) for: (b) Lac and glycomacromolecules 4, 6, 10 and 12 with increasing valency; (c) glycomacromolecules 4, 8–11 with decreasing spacing and (d) glycomacromolecules 5–7 and their propyl-Lac counterparts 13–15. RIP are referenced to the IC50 value of lactose.
