Fig. 5. Results from the reduced IC50 SPR inhibition experiment of Gal-3 with samples 4–15. (a) Exemplary SPR-sensorgrams of only Gal-3 and Gal-3 incubated with macromolecule 4, 8–11. (b and c) Gal-3 binding signal ± SD [%] with reference of only Gal-3 signal as 100% binding for (b) glycomacromolecules 4, 6, 10 and F with increasing valency; (c) glycomacromolecules 4, 8–11 with decreasing spacing and (d) glycomacromolecules 5–7 and their propyl Lac counterparts 13–15. All measurements were performed in triplicates.
