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. 2021 Sep 22;12(3):1363–1376. doi: 10.1016/j.apsb.2021.09.016

Figure 4.

Figure 4

[64Cu]DPA PET imaging of PD-L1 overexpressed U87MG tumor. (A) Flow cytometry analysis of PD-L1 expression in U87MG cell line. SSC: side scatter. (B) PD-L1 positive U87MG cells counted by flow cytometry. Data represent mean ± SD, ∗∗∗∗P < 0.0001, two-tailed Student's t-test. (C) Immunofluorescence imaging of PD-L1 in U87MG cells. Scale bar: 100 μm. (D) Co-registered PET/CT MIP images of BALB/c nude mice bearing U87MG tumors after intravenous injection of approximately 0.5 mCi of [64Cu]DPA for 60 min. The white dashed circle indicates the tumor position. (E) PET image-derived time–activity curves (0–60 min) of U87MG tumor, heart, and kidney in BALB/c nude mice bearing U87MG tumors after intravenous injection of [64Cu]DPA.