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Methods for generating d-type lead peptides and whole-body tracking of d-peptides via PET imaging. (A) Mirror-image phage display for generating highly potent d-peptides for target binding. (B) Structure of a tetrapeptide and its retro-inverse analog. (C) Comparison of l-peptides with d-peptides in terms of pharmacological properties. DMPK: drug metabolism and pharmacokinetics. (D) Whole-body tracking of d-peptides for in vivo fate study using PET imaging.
