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. 2021 Sep 30;12(3):1054–1067. doi: 10.1016/j.apsb.2021.09.028

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© 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Frequent genetic alterations in human esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC). The data of genetic alterations in human ESCC and EAC were collected from cBioPortal, www.cbioportal.org, accessed in April 2021 (Tables S1–S4). The top 15 cancer-related genes with highest rate in mutation (A) or copy number variation (B) in ESCC and EAC were presented as a Venn diagram. Genes in red have been reported to be associated with esophageal cancer and are or potentially are therapeutic targets. ∗EGFR has been verified as a promising target to treat ESCC though it is not among the top 15 altered genes.