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Significantly dysregulated pathways in human ESCC (A) and EAC (B). The most altered genes were classified into three signaling pathways. The frequency of genetic alterations in ESCC and EAC were retrieved from cBioPortal (www.cbioportal.org, accessed in April 2021.). (a) RTK–MAPK–PI3K signaling. (b) Cell cycle regulation. (c) Epigenetic modulation.
