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. 2021 Nov 9;12(3):1305–1321. doi: 10.1016/j.apsb.2021.11.002

Figure 2.

Figure 2

Effects of RG108 on cisplatin-induced cochlear SGNs damage in vitro. (A) Immunofluorescence staining for Tuj-1 (red) and myosin7a (green) in the middle turns of the cochleae from each treatment group. Scale bars = 20 μm. (B) Immunofluorescence staining for Tuj-1 (red), myosin7a (white) and TUNEL (green) in the middle turns of the cochleae. Scale bars = 20 μm. (C)–(E) Quantification analysis of SGN soma densities, neurite densities, and the length of neurite outgrowth from the middle turns of cochlear explants for all treatment conditions (each group, n = 12 SGN explants). Data are shown as mean ± SEM; ∗∗∗∗P < 0.0001 vs. Con; ####P < 0.0001 vs. Cis. Cis, cisplatin; SGNs, spiral ganglion neurons.