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. 2021 Nov 9;12(3):1305–1321. doi: 10.1016/j.apsb.2021.11.002

Figure 7.

Figure 7

Effect of RG108 on the transcriptome profiles of HEI-OC1 cells in response to cisplatin stimulation. (A) Volcano plot showing dysregulated genes between cisplatin and RG108 + cisplatin groups. (B) KEGG based gene function analysis showing the top 20 most affected pathways after RG108 treatment in HEI-OC1 cells. (C) Heat map of differentially expressed apoptosis-related genes in HEI-OC1 cells treated with cisplatin or RG108 + cisplatin. (D) The relative mRNA levels of the indicated genes were normalized to the GAPDH level in the HEI-OC1 cells treated with cisplatin or RG108 + cisplatin as determined by qRT-PCR. The results are expressed as mean ± SEM of three independent experiments. ∗∗∗∗P < 0.0001 vs. Con; ####P < 0.0001 vs. Cis.