The oxidative cyclization between acetophenone oxime acetate and phenylacetic acid utilizing different catalystsa.
Entry | Homogeneous catalyst | Heterogeneous catalyst | Yieldb (%) |
---|---|---|---|
1 | FeCl3 | 26 | |
2 | FeCl2 | 6 | |
3 | Fe(NO3)3 | 3 | |
4 | FeSO4 | 13 | |
5 | CuSO4 | 57 | |
6 | Cu(NO3)2 | 8 | |
7 | NiSO4 | 38 | |
8 | Co(NO3)2 | 4 | |
9 | La(NO3)2 | 2 | |
10 | Sr(NO3)2 | 39 | |
11 | Cu(BDC) | 70 | |
12 | ZIF-8A | 60 | |
13 | UiO-66·TFA | 43 | |
14 | La2O3 | 19 | |
15 | CoO | 11 | |
16 | SrO | 38 | |
17 | LaCoCo3 | 40 | |
18 | La0.6Sr0.4CoO3 | 83 |
Reaction conditions: acetophenone oxime acetate (0.6 mmol), phenylacetic acid (0.2 mmol), DTBP (0.6 mmol), toluene (2 mL), catalyst (5 mol%), 140 °C, under air for 2 h and under argon for 6 h.
GC yield.