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. 2022 Jan 21;12(3):1068–1099. doi: 10.1016/j.apsb.2022.01.009

Table 3.

Reported optical substrates for human MAOs.

Enzyme No. Substrate Metabolite Km (μmol/L) Vmax or Kcat λex/λem (nm) Ref.
MAOs MAOs-F1 Image 153 Image 154 218 Kcat = 7.25 S‒1 343/393 40
MAOs MAOs-F2 Image 155 Image 156 510 for MAO-B; 31 for MAO-A Kcat=0.35 S‒1
Kcat=0.0083 S‒1 		335/524 41
MAOs MAOs-F3 Image 157 Image 158 MR1: 7.6 mmol/L for MAO A, 1.8 mmol/L for MAO B MR2: 6.3 mmol/L for MAO-A, 3.4 mmol/L for MAO-B N.A. 550/583 42
MAOs MAOs-F4 Image 159 Image 160 146.1±7.21 for MAO-A; 106.8 ±5.06 for MAO-B Kcat = 0.16 S‒1 for MAO-A; 0.14 S‒1 for MAO-B 360/530 43
MAOs MAOs-F5 Image 161 Image 162 N.A. N.A. 345/465 44
MAOs MAOs-F6 Image 163 Image 164 Substrate1: 11.4 for MAO-A, 7.7 for MAO-B; Substrate2: 8.9 for MAO-A, 6.8 for MAO-B; Substrate3: 20.6 for MAO-A, 11.4 for MAO-B; Substrate4: 11.4 for MAO-A, 10.5 for MAO-B N.A. 470/535 45
MAOs MAOs-F7 Image 165 Image 166 N.A. N.A. 420/664 46
MAOs MAOs-F8 Image 167 Image 168 68±8 for MAO-A; 74 6 for MAO-B N.A. 448/585 47
MAOs MAOs-F9 Image 169 Image 170 Substrate1: 257.9 for MAOA, 47.1 for MAOB; Substrate2: 236.8 for MAOA, 43.9 for MAOB; Substrate3: 217.0 for MAOA, 42.9 for MAOB; Substrate4: 246.2 for MAOA, 44.6 for MAOB N.A. 470/515 190
MAOs MAOs-F10 Image 171 Image 172 Substrate1: 647.2 for MAO-A, 157.1 for MAO-B; Substrate2: 82.1 for MAO-A, 13.8 for MAO-B N.A. 475/570 52
MAO-A MAO-A-F1 Image 173 Image 174 N.A. N.A. 425/550 53
MAO-A MAO-A-F2 Image 175 Image 176 N.A. N.A. 425/550 54
MAO-A MAO-A-F3 Image 177 Image 178 2.9 N.A. 550/586 55
MAO-A MAO-A-F4 Image 179 Image 180 4.5 N.A. 530/675 56
MAO-A MAO-A-F5 Image 181 Image 182 11.96 Vmax=0.42 nmol/min/mg 430/618 58
MAO-B MAO-B-F1 Image 183 Image 184 N.A. N.A. 375/456 48
MAO-B MAO-B-F2 Image 185 Image 186 8.33 Kcat = 0.0051 S‒1 304/449 49
MAO-B MAO-B-F3 Image 187 Image 188 10.13 Vmax=3.55 nmol/min/mg 650/750
730/803		 50
MAO-B MAO-B-F4 Image 189 Image 190 59.63 Vmax=1.42 nmol/min/mg 360/460 51