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. 2022 Jan 21;12(3):1068–1099. doi: 10.1016/j.apsb.2022.01.009

Table 7.

Reported optical probes for human UGTs.

Enzyme No. Substrate Metabolite Km (μmol/L) Vmax (μmol/min/mg) or Kcat λex/λem (nm) Ref.
UGTs UGTs-F1 Image 255 Image 256 260 for UGT1A6; 8.0 for UGT1A7; 28 for UGT1A10; 4.5 for UGT2A1 0.052 for UGT1A6; 0.0027 for UGT1A7; 0.0108 for UGT1A10; 0.0062 for UGT2A1 364/498 96
UGTs UGTs-F2 Image 257 Image 258 3.1 for UGT1A6; 87 for UGT1A8; 2.0 for UGT1A10 0.0196 for UGT1A6; 0.001 for UGT1A8; 0.0013 290/330 97
UGTs UGTs-F3 Image 259 Image 260 N.A. N.A. 360/450 101
UGT1A10 UGT1A10-F1 Image 261 Image 262 3.4 16.4 405/460 100
UGT1A10 UGT1A10-F2 Image 263 Image 264 7.0 5.3 405/460 100
UGT1A10 UGT1A10-F3 Image 265 Image 266 2.2 5.9 405/460 100
UGT1A10 UGT1A10-F4 Image 267 Image 268 3.9 22.4 405/460 100
UGT1A1 UGT1A1-F1 Image 269 Image 270 2.7 for UGT1A1 Vmax = 0.966 μmol/min/L N.A. 99
UGT1A1 UGT1A1-F2 Image 271 Image 272 126.7 1303 450/564
362/450		 102
UGT1A1 UGT1A1-F3 Image 273 Image 274 0.7 561 370/520 103
UGT1A1 UGT1A1-F4 Image 275 Image 276 N.A. N.A. 670/720 106
UGT1A7c UGT1A7c-F1 Image 277 Image 278 N.A. N.A. 544/612 104
UGT1A8 UGT1A8-F1 Image 279 Image 280 1.35 N.A. 500/580 193