Table 8.
Reported optical probes for mammalian COMT.
| Enzyme | No. | Substrate | Metabolite | Km (μmol/L) | Vmax (μmol/min/mg) | λex/λem (nm) | Ref. |
|---|---|---|---|---|---|---|---|
| COMT | COMT-F1 |  |
 |
N.A. | 0.0924×10‒3 | N.A. | 107 |
| COMT | COMT-F2 |  |
 |
142 | N.A. | N.A. | 108 |
| COMT | COMT-F3 |  |
 |
8.04 | N.A. | N.A. | 109 |
| COMT | COMT-F4 |  |
 |
366 for S-COMT; 12 for MB-COMT | 22.9 for S-COMT; 4.62 for MB-COMT | 430/505 | 110 |
| COMT | COMT-F5 |  |
 |
510 | 0.0062×10‒3 | 430/505 | 111 |
| COMT | COMT-F6 |  |
 |
N.A. | N.A. | 349/393;347/389 | 112 |
| COMT | COMT-F7 |  |
 |
2.1 for m-MNT 3.2 for p-MNT |
N.A. | 348/390 | 113 |
| COMT | COMT-F8 |  |
 |
44 | 0.295×10‒3 | 295/340 | 114 |
| COMT | COMT-F9 |  |
 |
5.17 | 0.123 | 320/520 | 115 |
| COMT | COMT-F10 |  |
 |
0.79 | 0.0445 | 390/510 | 116 |