Table 1:
Overview on drug regimens used for PIPAC, HIPEC, and systemic treatment.
| PIPAC dose, mg/m2 | IV dose, mg/m2 | HIPEC dose, mg/m2 | NIPS dose, mg/m2 | PIPAC/IV % | PIPAC/HIPEC, % | |
|---|---|---|---|---|---|---|
| Ox | 46–135 | 85 | 200–460 | 85–130 | 50–160 | 10–30 |
| Dox | 1.5–2.1 | 15 | 15a | NA | 10–13 | 10 |
| Cis | 7.5–10.5 | 75 | 50a | NA | 10–13 | 15–21 |
| MMC | 1.5 (14 mg total dose)c | 20 | 10–35 | NA | 43–75 | 4–15 |
| Iri | 20c | 125–180 | 200 | NA | 11–16 | 10 (0.1) |
| Ptx | 30b | 135–175 | 60–175 | 20–80 | 17–22 | 17–50 |
| Nab-Ptx | 112,5 | 125 | NA | NA | 90 | NA |
aDoses only used for the combination of drugs, not for the independent use of each drug; bdose based only on animal studies; cdoses based on expert opinion and not published in the literature.