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. 2022 May 3;18:17448069221097760. doi: 10.1177/17448069221097760

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© The Author(s) 2022

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — MSU-induced mouse gout model and overview of transcriptomes of the injected ankle joint, DRG, and spinal cord. a. Representative photos showing mouse ankle joints injected with 1 x PBS or MSU. The pictures were taken 8 h after injections. b. Von Frey filament tests showing mechanic allodynia of MSU-injected mice (n = 6 mice/group). c. Swelling degree of MSU-injected mice as indicated by increased ankle diameter (n = 6 mice/group). d. Tissue-based principal component analyses (PCA) of mouse RNAseq under gout condition showed clustering and clear separation for three different types of tissues and between case and control samples of each tissue (n = 3 mice/group).