Table 4.
Results of association of FGF-21 ≧ 1.40 pg/dl and renal composite events stratified by age, sex, blood pressure, eGFR, UACR, and the use of RAS inhibitors.
| Renal composite events Subgroup | Crude HR | 95% CI | P-value for Interaction |
|---|---|---|---|
| Age ≧ 60 y/o(n=190) | 2.18 | 1.15–4.11 | 0.88 |
| Age < 60 y/o (n=122) | 5.97 | 1.33–26.69 | |
| Male (n=213) | 3.43 | 1.55–7.55 | 0.57 |
| Female (n=99) | 1.75 | 0.74–4.13 | |
| SBP ≧ 140 mmHg (n=96) | 1.58 | 0.63–3.96 | 0.32 |
| SBP < 140 mmHg (n=216) | 3.80 | 1.76–8.19 | |
| eGFR ≧ 60 ml/min/1.73m2 (n=247) | 2.18 | 1.15–4.11 | 0.19 |
| eGFR < 60 ml/min/1.73m2 (n = 65) | 5.97 | 1.33–26.69 | |
| UACR ≧ 30 mg/g Cr (n=112) | 4.02 | 1.55–10.41 | 0.02 |
| UACR < 30 mg/g Cr (n=200) | 1.80 | 0.83–3.87 | |
| RAS inhibitors (n=154) | 2.76 | 1.28–5.97 | 0.08 |
| No RAS inhibitors (n=158) | 2.11 | 0.84–5.30 |
eGFR, estimated glomerular filtration rate; UACR, urinary albumin-to-creatinine ratio; RAS, renin–angiotensin system; SBP, systolic blood pressure; HR, hazard ratio; CI, confidence interval.