. 2022 May 5;22:894. doi: 10.1186/s12889-022-13299-2

Table 1.

Repeated measures ANOVA for change in depressive symptoms, anxiety symptoms and QoL over time*

Dependent Variable		F-value	p-value (change over time)	Trimester 1 (mean ± SE)	Trimester 2 (mean ± SE)	Trimester 3 (mean ± SE)
Factor scores	Depressive symptoms	4.22	0.0158	5.40 ± 0.34^a	4.21 ± 0.44^b	4.00 ± 0.45^b
	Total Anxiety symptoms	20.83	< 0.0001	5.66 ± 0.43^a	2.65 ± 0.54^b	2.00 ± 0.54^b
	Fear Factor	8.39	0.0003	1.56 ± 0.17^a	0.84 ± 0.22^b	0.56 ± 0.22^b
	Nervous Factor	16.68	< 0.0001	1.69 ± 0.14^a	0.61 ± 0.17^b	0.88 ± 0.18^b
	Panic Factor	8.53	0.0003	1.07 ± 0.12^a	0.63 ± 0.16^a,b	0.25 ± 0.16^b
	Somatic Factor	20.43	< 0.0001	2.32 ± 0.69^a	1.56 ± 0.70^b	1.32 ± 0.71^b
	Total QoL	9.85	< 0.0001	34.24 ± 1.24^a	36.05 ± 1.58^a	27.25 ± 1.59^b
	Physical Health	22.14	< 0.0001	48.04 ± 1.45^a	44.15 ± 1.45^a	35.91 ± 1.46^b
	Role Physical	6.21	0.0023	28.25 ± 2.34^a	29.25 ± 2.98^a	16.74 ± 2.99^b
	Role Emotional	4.18	0.0163	40.65 ± 2.54^a,b	43.89 ± 3.22^a	31.89 ± 3.24^b
	GHV	24.46	< 0.0001	19.74 ± 0.72^a	26.95 ± 0.91^b	24.46 ± 0.92^b

*Means with different letter superscripts within a row are significantly different. QoL quality of life, GHV general health/vitality