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. 2022 May 5;41:165. doi: 10.1186/s13046-022-02368-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 9 — Overexpression of circ_0087429 in vivo can inhibit the progression of cervical cancer a. Image of subcutaneous tumour tissues in the circ_0087429-overexpressing group and control group. b-c. Volume and weight of subcutaneous tumour tissues in each group. d. The expression levels of circ_0087429, miR-5003-3p and OGN in subcutaneous tumour tissues of each group were detected by qRT-PCR. e–f. The expression levels of OGN, N-cadherin and E-cadherin in subcutaneous tumour tissues of each group were detected by western blotting. g-h. The expression levels of OGN, N-cadherin, E-cadherin, Ki67 and CD31 in subcutaneous tumour tissues of each group were detected by immunohistochemical staining. Scale bar, 30 μm. i-l. Representative images and bar graphs of liver (i-j) and lung (k-l) metastases with circ_0087429-overexpressing group and control group in a nude mouse metastatic tumour model. Metastatic nodules are indicated by arrows. Scale bar, 60 μm. m. A schematic diagram showing how circ_0087429 regulates the expression of OGN by sponging miR-5003-3p and thereby reverses EMT. MET: mesenchymal to epithelial transition. *p < 0.05, **p < 0.01, ***p < 0.001