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. 2022 May 5;41:164. doi: 10.1186/s13046-022-02378-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — circTOLLIP promotes the proliferation and migration of HCC cells in vitro and in vivo. a-c The colony formation assay and CCK-8 assay were performed in HLF and 97H cells. d-f The statistic graphs of scratch wound healing assay and cell migration and invasion assays. g The subcutaneous xenograft tumors from vector or overexpressed circTOLLIP 97H cells. h-i Tumor weight and tumor volume of subcutaneous xenografts. j-k Liver orthotopic transplantation and metastasis models in nude mice with circTOLLIP-overexpressing and vector HLF cells. Representative pictures are presented that show HE staining of isolated liver tissue and a general image of the whole liver. The number of visible tumor nodules was counted and pointed by red arrows. l-p Lung metastasis assay was performed with 97H-circTOLLIP cells in nude mice by tail vein injection. Representative pictures showing lung metastatic nodules, the incidence of lung metastasis (l), HE staining of lung tissue (m) and lung fluorescence imaging (o, p) were presented. The number of lung metastatic nodules was counted in lung tissues after HE staining(n)