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. 2022 May 5;23:172. doi: 10.1186/s12882-022-02801-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Bioenrichment analysis of differential expression RBPs. A-B Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, screening criteria as p < 0.05, q < 0.05 (Adjusted p value). DERBPs are enriched for relevant biological co-energies and associated molecular signalling pathways (BP:biological process CC: cell component MF: molecular function). C DERBPs protein–protein interaction network. The connections in the network represent interactions among genes, with green representing down-regulated genes and red up-regulated genes (Confidence = 0.7). D Number of node connections in a PPI network. The connections of the first 30 genes are displayed by the number of node connections. E RBPs associated with survival were screened by univariate Cox regression analysis (p < 0.0001)