Fig. 7. (a) Representative in vivo near-infrared fluorescence assortments of PSS-794, Tracer-794, and Annexin-Vivo 750 accumulations in a brain cryoinjury mouse model. A precooled metal cylinder was applied to the head of each mouse for 60 s followed by intravenous injection of either PSS794 (3.0 mg kg−1), Tracer-794 (3.0 mg kg−1), or Annexin-Vivo 750. Images were acquired at the indicated time points after probe injection. N = 5. (left) Multicolor fluorescence ex vivo imaging of cell death and blood brain-barrier disruption in cryoinjured brains (right). Reproduced with permission from ref. 113. Copyright 2012, American Chemical Society. (b) Confocal images of vessel painted vasculature at the perilesional region for Sham and TBI. Cal bar = 200 μm (top). Classical vascular analysis using AngioTool imaging software. Axial vessels are displayed (red) and junctions (blue). Reproduced with permission from ref. 114. Copyright 2017, Nature Publishing Group. (c) Two-photon Fluorescence Micro endoscope. Computer aided design (CAD) (part 1), top view of entire setup (part 2), internal components (part 3), mechanism of light collection (part 4). Reproduced with permission from ref. 115. Copyright 2005, The Optical Society. (d) Image of a 3 mm outer diameter multiphoton endoscope. Reproduced with permission from ref. 116. Copyright 2011, National Academy of Sciences.
