Summary of metabolites of eriocitrin in rat liver microsomes^a.

Metabolites ID	Composition	Formula	m/z	Error (ppm)	R.T. (min)	Score (%)	MS/MS fragments	clog P	Blanks	Controls	Samples
N1	Loss of C6H10O5 [M − H]−	C21H22O10	433.1159	4.4	15.87	85.9	417.0309, 353.1632, 271.0645, 135.2507	0.83947	−	−	+
N2	Loss of C12H20O9 [M − H]−	C15H12O6	287.0562	0.4	15.59	96.3	269.0391, 241.2241, 151.0039, 135.0451, 125.0236	1.84785	−	−	+
N3	Desaturation [M − H]−	C27H30O15	593.1508	−0.6	12.59	95.4	549.1892, 447.0645, 285.0406, 151.0032	−0.21048	−	−	+
N4	Loss of C6H10O4 + loss of water [M − H]−	C21H20O10	431.0976	−1.7	14.49	76.6	399.0170, 387.0883, 313.0631, 269.0528	1.62817	−	−	+
N5	Loss of C6H10O5 + hydrogenation [M − H]−	C21H24O10	435.1320	5.4	15.66	67.4	389.1652, 298.9101, 273.0560, 153.0836, 135.0666	−0.52288	−	−	+
N6	Loss of C6H10O4 + N-acetylation [M − H]−	C23H24O12	491.1161	−7.0	15.42	64.0	473.2817, 445.1889, 287.1221, 125.0191	0.53447	−	−	+
N7	Loss of C6H10O5 + demethylation to carboxylic acid [M − H]−	C21H20O12	463.0868	−3.0	12.86	83.0	417.1839, 271.0245, 258.9180, 151.0005	−0.19068	−	−	+
N8	Loss of C6H10O5 + ketone formation [M − H]−	C21H20O11	447.0925	−1.9	13.67	80.6	429.3176, 301.0338, 285.0364, 151.0020	−0.06953	−	−	+
N9	Loss of C12H20O10 + ketone formation [M − H]−	C15H10O6	285.0406	0.4	15.85	84.6	267.1811, 257.0448, 239.0672, 223.0274, 119.0614	1.48794	−	−	+
N10	Oxidation [M − H]−	C27H32O16	611.1615	−0.3	12.39	78.9	303.0505, 287.0565, 227.9309, 151.0036, 135.0468	−1.45408	−	−	+
N11	Loss of C6H10O5 + methylation [M − H]−	C22H24O10	447.1328	6.9	23.89	65.2	417.1216, 285.1388, 148.9971, 135.0752	0.662468	−	−	+
N12	Loss of C12H20O9 + oxidation and methylation [M − H]−	C16H14O7	317.0694	8.6	16.61	70.4	299.0555, 273.0489, 180.9719, 165.0828	1.30533	−	−	+

^a+ detected; − undetected.