TABLE 3.
Susceptibilities of M. pneumoniae to new antimicrobial agentsa compared with those to older reference agents
| Agent (no. of strains) | MIC (μg/ml)
|
||
|---|---|---|---|
| Range | 50% | 90% | |
| New agents | |||
| Linezolid (24) | >64 | >64 | >64 |
| Evernimicin (40) | 2.0–4.0 | 4.0 | 4.0 |
| Tetracyclines, glycylcycline (GAR-936) | |||
| GAR-936 (30) | 0.06–0.25 | 0.12 | 0.25 |
| Tetracycline (30) | 0.5–2.0 | 0.5 | 1.0 |
| Minocycline (30) | 0.25–1.0 | 0.5 | 1.0 |
| Macrolides, lincosamide, streptogramins, ketolide | |||
| Dirithromycin (45) | 0.12–0.5 | 0.25 | 0.25 |
| Dalfopristin (48) | 0.06–1.0 | 0.25 | 0.5 |
| Quinupristin-dalfopristin (48) | 0.004–0.06 | 0.015 | 0.03 |
| Telithromycin (47) | 0.008–0.06 | 0.008 | 0.008 |
| Azithromycin (45) | 0.008–0.12 | 0.015 | 0.03 |
| Clarithromycin (45) | 0.015–0.06 | 0.03 | 0.03 |
| Erythromycin (45) | 0.03–0.12 | 0.06 | 0.06 |
| Roxithromycin (40) | 0.06–0.25 | 0.12 | 0.25 |
| Josamycin (21) | 0.03–0.12 | 0.03 | 0.06 |
| Quinolones | |||
| Gatifloxacin (41) | 0.25–1.0 | 0.25 | 0.5 |
| Grepafloxacin (41) | 0.06–0.25 | 0.12 | 0.25 |
| Levofloxacin (41) | 0.5–2.0 | 1.0 | 2.0 |
| Moxifloxacin (35) | 0.12 | 0.12 | 0.12 |
| Sparfloxacin (40) | 0.12–0.25 | 0.25 | 0.25 |
| Trovafloxacin (40) | 0.12–0.5 | 0.25 | 0.5 |
Bold type indicates new agents.