Cytotoxicity (IC50) values of the studies α-aminophosphonates.
| Compound | Compound structure | T98G IC50 [μM] | U-118 MG IC50 [μM] | HaCaT IC50 [μM] |
|---|---|---|---|---|
| 1a |
|
40.4 ± 6.2 | 60.67 ± 8.9 | 56.8 ± 7.4 |
| 1b |
|
73.5 ± 9.2 | 88.2 ± 7.5 | >100 |
| 1c |
|
67.9 ± 11.2 | 91.2 ± 15.5 | >100 |
| 1d |
|
71.3 ± 8.7 | 48.6 ± 10.4 | 67.9 ± 11.8 |
| 1e |
|
106.4 ± 14.7 | 86.8 ± 7.2 | 61.8 ± 9.1 |
| 1f |
|
25.1 ± 4.5 | 40.8 ± 8.4 | 33.2 ± 5.1 |
| 2b |
|
14.5 ± 3.3 | 37.9 ± 2.5 | 26.5 ± 4.7 |
| 2d |
|
36.8 ± 5.7 | 33.2 ± 7.3 | 19.8 ± 3.9 |
| 2e |
|
20.4 ± 3.1 | 21.4 ± 2.7 | 10.1 ± 2.2 |
| 2f |
|
25.5 ± 1.9 | 28.1 ± 3.6 | 18.2 ± 3.4 |
| 2j |
|
82.7 ± 15.7 | >100 | >100 |
| 2r |
|
70.3 ± 8.3 | 79.2 ± 6.4 | 48.4 ± 7.4 |
| 5-FdU (5-fluoro-2′-deoxyuridine) |
|
5.57 ± 0.9 | 23.40 ± 1.6 | 4.42 ± 1.1 |