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. 2022 Apr 28;386(17):1638–1645. doi: 10.1056/NEJMra2200583

Table 1. Viral Zoonotic Outbreaks since 1993.*.

Year Identified Pathogen or Disease Location Where Disease First Described Mortality Percentage Viral Category Source
1993 Sin Nombre virus New Mexico About 35 Bunyavirus Rodents, especially deer mice (Peromyscus maniculatus)
1999 Nipah virus Malaysia About 70 Paramyxovirus
  • Reservoir: fruit bats

  • Vector: pigs, contaminated fruit

1999 West Nile virus Uganda <1 Flavivirus
  • Reservoir: birds

  • Vector: culex mosquitoes

2002 SARS-CoV-1 China 9 Coronavirus
  • Reservoir: horseshoe bats

  • Vector: palm civets

2009 Pandemic influenza A (H1N1) virus Mexico 2 Orthomyxovirus Swine
2012 Middle East respiratory syndrome virus Saudi Arabia and Jordan 30 Coronavirus
  • Reservoir: bats

  • Vector: dromedaries

2012 Acute flaccid myelitis St. Louis <1 Nonpolio enteroviruses
  • Reservoir: humans

  • Fecal–oral spread

2013 Ebola virus Uganda and Tanzania 50 Filovirus
  • Reservoir: monkeys

  • Vector: nonhuman primates

2015 Zika virus Uganda 8 Flavivirus
  • Reservoir: monkeys

  • Vector: aedes mosquitoes

2019 SARS-CoV-2 China <2 Coronavirus Bats
*

SARS-CoV-1 and SARS-CoV-2 denote severe acute respiratory syndrome coronavirus 1 and 2.

Sin Nombre virus is the causative agent of hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome.