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. 2022 Apr 28;386(17):1638–1645. doi: 10.1056/NEJMra2200583

Table 2. Categories of Infectious Diseases.

Category Definition
Pandemic An epidemic that spreads between countries (e.g., Covid-19 was an epidemic when limited to China; with global spread, it became a pandemic)*
Epidemic Sudden increase in cases above the expected incidence in a region where the disease is not permanently prevalent and is spreading from person to person
Endemic Infection that is maintained at a baseline level in a geographic area; the infectious agent is always present in the population
Outbreak Greater-than-anticipated increase in the number of cases of an endemic illness; if not quickly controlled, an outbreak can become an epidemic
Cluster Increase above the number of expected cases in a place or time period
Sporadic disease Disease that occurs infrequently and irregularly
*

Covid-19 denotes coronavirus disease 2019.