| 1955 |
“Cutter Incident” involving killed polio vaccine |
Some vaccine lots contained live poliovirus, resulting in cases of poliomyelitis |
Increased regulation and oversight of vaccine manufacturing |
| 1955–1963 |
10–30% of vaccines derived from monkey kidney cells contained simian virus 40 |
Prolonged follow-up showed no association with cancer in humans |
No vaccines today contain simian virus 40 |
| 1976 |
Swine influenza vaccine associated with Guillain–Barré syndrome |
Increased risk of approximately 1 case per 100,000 vaccinees |
Influenza vaccines are monitored each year |
| 1998 |
Hepatitis B vaccine possibly associated with multiple sclerosis |
Thorough review by Institute of Medicine showed no association |
|
| 1998 |
Rotavirus vaccine associated with intussusception |
|
Vaccine was removed from market |
| 2005 |
Meningococcal vaccine possibly associated with Guillain–Barré syndrome |
Thorough review of cases showed no association |
|
| 2007 |
Haemophilus influenzae type b vaccine contaminated with Bacillus cereus
|
No cases of bacterial infection found in vaccine recipients |
Vaccine was recalled |
| 2009 |
Pandemic influenza A (H1N1) vaccine associated with narcolepsy |
Evaluation found an association in only one country (Finland) with one adjuvanted influenza vaccine |
Vaccine was modified |
| 2010 |
Rotavirus vaccine associated with porcine circovirus |
Safety monitoring showed no safety issue in humans |
|
| 2013 |
Human papillomavirus vaccine vials contaminated with glass particles |
Manufacturing error in one lot; no health problems reported |
Lot was recalled |
| 2017 |
Dengue vaccine associated with risk of severe dengue virus infection, depending on serostatus of recipient |
Dengue-seronegative recipients of dengue vaccine are at risk for severe dengue if breakthrough infection occurs |
Guidelines recommend serologic testing before vaccination and vaccine administration only in seropositive persons |
