Table 4. Issues That the FDA and CDC Consider When Determining Vaccine Licensure and Recommendations.^*.

Safety

Efficacy

Equity

Public health effect

Cost effectiveness

Effect on community (herd) immunity

Vaccine supply and storage

Compatibility with existing vaccine schedule

Public acceptance of vaccine

Age when disease is most likely to occur

Effect of age on immune response

Duration of immune response

Need for boosters

Minimizing number of doses

Simplification of immunization schedule

^*CDC denotes Centers for Disease Control and Prevention, and FDA Food and Drug Administration.