Fig. 1. 3D response surface plot screening effect of independent variables (a) cholesterol acrylate concentration (X1) and CAP concentration (X2) (b) cholesterol acrylate concentration (X1) and sonication time (X3) (c) CAP concentration (X2) and sonication time (X3) on particle size (Y1) and entrapment efficiency (Y2) (note: region in the red represents maxima and region in blue represents minima).