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. 2019 Aug 12;9(43):24987–24994. doi: 10.1039/c9ra04814f

Independent and dependent variables.

Factors Levels
Low (−1) Medium (0) High (+1)
Independent variables
X1 (mg) (THP-CL) 262.2 500 737.8
X2 (mg) (CAP) 16.1 25 33.9
X3 (min) (sonication time) 3 6 9
Dependent variables
Y1 (particle size) Minimize
Y2 (entrapment efficiency) Maximize