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. 2022 Apr 12;13:807125. doi: 10.3389/fphar.2022.807125

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Copyright © 2022 Xu, Li, Liu, Lu, Ling and Gong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Rutaecarpine reduces apoptosis in PC12 cells in response to H2O2-induced oxidative stress. (A) Flow assay for apoptosis in each group. (B) The relative apoptosis cells in each group. (C) Expressions of apoptosis-related proteins cleaved-Caspase-3, Caspase-3, Bcl-2 and Bax in PC12 cells. Relative expressions of (D) cleaved-Caspase-3/Caspase-3, (E) Bcl-2 and (F) Bax of PC12 cells in each group. GAPDH was used as an internal control for proteins in (C). Compared with the control group, #p < 0.05 and ##p < 0.01; compared with the model group, *p < 0.05 and **p < 0.01.