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. 2022 Apr 12;13:807125. doi: 10.3389/fphar.2022.807125

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Copyright © 2022 Xu, Li, Liu, Lu, Ling and Gong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Rutaecarpine regulates the ubiquitinated degradation of PGK1. (A) Representative images of PGK1 in PC12 cells. (B) Relative expression of PGK1. (C) The relative mRNA expression of PGK1 in PC12 cells. (D) With increasing time, rutaecarpine further reduced the expression of PGK1. (E) The relative expression of PGK1 was presented in histograms. (F) Rutaecarpine further promotes PGK1 ubiquitination on the basis of MG-132. (G) The relative expression of PGK1 was presented in histograms. GAPDH was used as an internal control for proteins in (A, D, F). Compared with the control group, #p < 0.05 and ##p < 0.01; compared with the model group, *p < 0.05 and **p < 0.01.