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. 2022 Jan 5;13(2):245–256. doi: 10.1021/acschemneuro.1c00653

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© 2022 The Authors. Published by American Chemical Society

Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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PC1/3 and PC2 cleavage profiling analyzed by MSP-MS. Volcano plots of PC1/3 (panel a) and PC2 (panel b) peptide cleavages from MSP-MS data show the log₂ ratios of relative quantities of peptide products generated by PC1/3 and PC2 (60 min incubation at pH 5.5) compared to no enzyme activity controls, illustrated by −log₁₀p values. Peptide products generated with at least a 5-fold change above controls and with p < 0.05 were analyzed for the frequencies of amino acid residues at the P4–P4′ positions of the P1–↓P1′ cleavage site.