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Fig. 4. Antibacterial effects of hBD3-3, TBP-1-hBD3-3, and TBP-1-RGDS-hBD3-3 against single-species (S. oralis, S. gordonii or S. sanguinis) biofilms. Biofilms treated with the three peptides (1/2 MIC) were incubated for 24 h (A) or 72 h (B). Data are shown as the mean ± SEM; n = 3. *P < 0.01 compared with the control groups.