Comparison of hemodynamic parameters of the mice groupsa.
| db/m | db/m + HED | db/db | db/db + HED | |
|---|---|---|---|---|
| HR (bpm) | 551 ± 2.9 | 553 ± 5.1 | 555 ± 6.6 | 553 ± 6.2 |
| ESP (mmHg) | 82.6 ± 5.92 | 81.3 ± 1.3 | 79.5 ± 7.9* | 78.8 ± 6.1Δ |
| EDP (mmHg) | 3.5 ± 1.1 | 4.9 ± 1.9 | 2.3 ± 1.1* | 2.8 ± 1.5Δ |
| dp/dtmax (mmHg s−1) | 7035 ± 268 | 6998 ± 367 | 6723 ± 158* | 6861 ± 256Δ |
| dp/dtmin (mmHg s−1) | −6992 ± 323 | −6916 ± 239 | −6578 ± 420* | −6727 ± 394Δ |
a
HR: heart rate, Pes: LV end systolic pressure, Ped: LV end diastolic pressure, dp/dtmax: maximal rates of rise of ventricular pressure, dp/dtmin: maximal rates of decline of ventricular pressure. Values are presented as mean ± S.D., *P < 0.01 vs. db/m, ΔP < 0.01 vs. db/db + HED.