TABLE 1.
In vitro activities of UR-9825 and amphotericin B against pathogenic mold isolates
| Species (no. of isolates) and antifungal agent | MIC (μg/ml)
|
||
|---|---|---|---|
| Range | 50% | 90% | |
| Aspergillus fumigatus (10) | |||
| UR-9825 | 0.06–0.125 | 0.06 | 0.125 |
| Amphotericin B | 1–2 | 1 | 2 |
| Aspergillus flavus (11) | |||
| UR-9825 | 0.06–0.25 | 0.125 | 0.25 |
| Amphotericin B | 0.25–4 | 1 | 2 |
| Aspergillus niger (11) | |||
| UR-9825 | 0.06–0.5 | 0.25 | 0.5 |
| Amphotericin B | 0.06–1 | 0.125 | 1 |
| Fusarium solani (10) | |||
| UR-9825 | 4–>16 | 16 | >16 |
| Amphotericin B | 1–2 | 2 | 2 |
| Paecilomyces variotii (10) | |||
| UR-9825 | 0.03–>16 | 0.06 | 0.125 |
| Amphotericin B | 0.125–1 | 0.25 | 0.5 |
| Paecilomyces lilacinus (10) | |||
| UR-9825 | 0.06–0.5 | 0.125 | 0.125 |
| Amphotericin B | >16 | >16 | >16 |
| Chaetomium globosum (10) | |||
| UR-9825 | 1–2 | 2 | 2 |
| Amphotericin B | 1–16 | 4 | 16 |
| Scytalidium lignicola (2) | |||
| UR-9825 | >16 | ||
| Amphotericin B | 2 | ||
| Scytalidium dimidiatum (3) | |||
| UR-9825 | 2–>16 | ||
| Amphotericin B | 2–4 | ||