Figure 4.

Enrichment of STAT5 binding sites (A) and hypophysectomy response class (B) for the sets of genes induced or repressed by STAT5_CA. (A) Data are shown for STAT5 binding sites that are male-biased (M; 1765 sites), female-biased (F; 1790 sites), and sex-independent (SI; 11 531 sites), as previously defined by ChIP-seq (9), and mapped to their target genes (nearest gene within 50 kb). Enrichments are expressed as the ratio of STAT5_CA-responsive genes compared with STAT5_CA-unresponsive genes that are associated with each of the 3 sets of STAT5 binding sites (see box at top). (B) Enrichment of class I or class II sex-biased genes (left) and sex-independent genes (right) in the STAT5_CA-responsive gene sets, expressed as the ratio of the number of STAT5_CA-responsive genes compared to the number of STAT5_CA-unresponsive genes in each class (left) or that are induced or repressed by hypophysectomy (right). Significance was determined by Fisher exact test: *P < 0.05, ***P < 0.001. Asterisks above the dashed line indicate significant enrichment; red asterisks below the dashed line indicate significant depletion (values < 1).