Unique simulation parameters for Model 1.

Sim #	NP radius (nm)	k on,R (M−1 s−1)	k off,R (s−1)	K D,R (nM)	k clear0 a (s−1)	Clearanceb
1	3	1 × 105	1 × 10−3	10	4.5 × 10−4	All
2	4	1 × 105	1 × 10−3	10	1.3 × 10−4	All
3	1	1 × 105	1 × 10−3	10	1.3 × 10−3	All
4	3	1 × 105	1 × 10−3	10	4.5 × 10−4	NPfree
5	4	1 × 105	1 × 10−3	10	1.3 × 10−4	NPfree
6	1	1 × 105	1 × 10−3	10	1.3 × 10−3	NPfree
7	3	1 × 105	1 × 10−1	1000	4.5 × 10−4	NPfree
8	1	1 × 103	1 × 10−5	10	1.3 × 10−3	NPfree

^aSystemic clearance rates (k_clear0, k_clear1, etc.) are calculated according to eqn (5). k_clear0 is shown for reference.

^bSim #1–3: NP clearance occurs through NP_free, NP_PC and NP_FC. Sim #4–8: NP clearance occurs through NP_free only.