Fig. 6. Biological profile of data sets of lactams with more than 50 compounds tested in human targets. The lactams are grouped according to their chemical classification (Fig. 2) and the targets are grouped according to their classification in ChEMBL. The size of each dot indicates the relative number of compounds. The colors of the data points denote the percentage of active compounds using a continuous scale (red, a lower percentage and green, a higher percentage). PF: protein family, PPI: protein–protein interaction.