Fig. 8. Chemotype enrichment plot. The abscissa indicate the enrichment factor (EF) as defined by eqn (1). Background activity is indicated by the vertical dashed line at EF = 1. The ordinate indicates the chemotype frequency in the database. Background frequency is indicated by the horizontal dashed line at frequency = 20. To facilitate the view, only scaffolds with EF up to 20 are displayed. Each of the data points in the figure corresponds to a chemotype that are further distinguished in color by class. The structure of the highlighted scaffolds can be seen in Fig. 9a.
