Cell viability (IC50 values) of GA derivatives 7a–7i against normal ovarian epithelial cells (IOSE80) and selectivity index (SI).
| Compounds | IC50a (μM) | SIb | |
|---|---|---|---|
| IOSE80 | SKOV3 | OVCAR3 | |
| 7a | 66.8 ± 0.9 | 1.1 | 1.3 |
| 7b | 48.4 ± 0.6 | 0.8 | 0.9 |
| 7c | 86.7 ± 0.9 | 3.1 | 2.6 |
| 7d | 65.7 ± 3.7 | — | 1.2 |
| 7e | 71.8 ± 1.9 | 1.6 | 1.3 |
| 7f | 92.0 ± 1.1 | 1.6 | 1.9 |
| 7g | 53.0 ± 0.8 | 1.1 | 1.2 |
| 7h | 97.6 ± 5.7 | 1.7 | 2.2 |
| 7i | >100 | — | — |
| GA | >100 | — | — |
| Paclitaxel | 1.7 ± 0.1 | 4.0 | 4.5 |
a
IC50: concentration that inhibits 50% of cell growth. The values are presented as the mean ± SD (standard error of the mean) from three separated experiments.
b
SI (selectivity index): IC50 IOSE80 cell line/IC50 ovarian cancer cell line.