TABLE 1.

Drugs, conditions, and results of compatibility studies mimicking the coadministration of ceftazidime with other drugs through the same line of infusion^a

Drug	Dose (mg)	Vol per administration (ml)	Time of infusion (h)	Drug:ceftazidime ratio in final infusate		Resultb
				Wt ratio	Molar ratio
Anti-infectives
Amikacin	1,500c	100	0.25	27.7	25.9	c
Isepamicin	1,500c	100	0.25	27.7	26.6	c
Tobramycin	600d	100	0.25	11.1	12.9	c
Gentamicin	600d	100	0.25	11.1	13.1	c
Vancomycin	1,500	50	1	9.0	3.3	I (phys)*
Erythromycin	1,000	20	0.33	13.9	10.3	I (phys)*
		100	0.33	12.4	9.2	c+
Clarithromycin	500	10	0.33	12.4	9.2	I (phys)*
		50	0.33	12.4	9.2	c+
Fluconazole	200	100	0.5	1.59	2.8	c
Sedatives/anticonvulsants
Ketamine	480	48	24	0.08	0.19	c
Propofol	300	300	24	0.05	0.17	I (phys)**
Sufentanil	0.12	24	24	1.98	2.8	c
Midazolam	600	120	24	0.1	0.17	I (phys)*
Valproic acid	1,200	12	24	0.2	0.76	c
Antihypertensives/diuretics
Nicardipine	120	120	24	0.02	0.02	I (phys)*
Uradipil	2,400	480	24	0.4	0.56	c
Furosemide	960	96	24	0.16	0.26	c
Miscellaneous
N-Acetylcystein	10,000	100	24	1.7	5.69	I (chim)
Amino acid solution	18,000e	1,000	24	30.1		c

^aAll conditions are meant to mimic one administration to a patient with a body weight of 100 kg; ceftazidime was assumed to be infused at a rate of 4 g/24 h in a volume of 48 ml. 

^bc, compatible (c⁺, very slight precipitate with complete recovery of ceftazidime upon dilution); I (phys), physically incompatible [I (phys)*, immediate precipitation; I (phys)**, trapping in emulsion]; I (chem), chemically incompatible (>10% ceftazidime degradation). 

^cDose, 15 mg/kg of body weight once daily. 

^dDose, 6 mg/kg, once daily. 

^eVAMIN (standard amino acid solution for parenteral nutrition). Dose was 18 g of amino acid nitrogen/liter.