Table 6.

Karius Test Performance Following Clinical Adjudication at All Timepoints

Timepoint (Days Since Fever Onset)	Sensitivity % (Frequency)	Specificity % (Frequency)	90% Confidence Interval	Positive Predictive Value (%)	Negative Predictive Value (%)
1	85.4 (41/48)		74.4–93	100
		100 (7/7)	65.2–100		50
2 (days 3–4)	94.1 (32/34)		82.6–98.9	97
		80 (4/5)	34.3–99		66.7
3 (days 5–7)	100 (22/22)		87.3–100	91.7
		33.3 (1/3)	1.7–86.5		100
4 (days 7–10)	94.4 (17/18)		76.2–99.7	89.5
		33. (1/3)	1.7–86.5		50
5 (days 9–13)	88.9 (8/9)		57.1–99.4	88.9
		50 (1/2)	2.5–97.5		50
Cumulative	91.6 (120/131)	70 (14/20)		93.4	63.3