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. 2021 Jul 29;74(9):1604–1613. doi: 10.1093/cid/ciab665

Figure 2.

Figure 2.

Effect of HIV on clearance of RPT in second-trimester and third-trimester trimester. There were no differences in RPT concentration between second-trimester data (intensive PK from cohort 1; left panel) and third-trimester data (intensive PK from cohort 2, sparse PK from cohort 1; right panel). RPT clearance was 30% higher in pregnant WLHIV (blue) compared with women without HIV (pink) (P < .001). Data deemed to be below the LLOQ are displayed as open black circles as the LLOQ value (0.039 μg/mL). Abbreviations: AUCSS, steady-state area under the concentration-time curve; HIV, human immunodeficiency virus; IQR, interquartile range; LLOQ, lower limit of quantification; PK, pharmacokinetics; RPT, rifapentine; RSE, relative standard error; WLHIV, women living with HIV.