Evaluation of the cytotoxicity and log IC50 values (μM) of chalcone compounds and docetaxel (reference chemotherapeutic drug) on two cancer cell linesa.
Compound | MCF-7 log IC50 (μM) | PC-3 log IC50 (μM) |
---|---|---|
D1 | 2.12 | 1.54 |
37a | 1.89 | 1.67 |
37b | 1.15 | 1.24 |
37c | 5.01 | 6.31 |
37d | 5.79 | 1.81 |
37e | 0.42 | 0.67 |
37d | 2.30 | 2.47 |
37f | 4.43 | 6.11 |
37g | 2.55 | 2.57 |
37h | 6.28 | 6.30 |
37i | −0.21 | 0.92 |
Docetaxel (reference drug) | −0.52 | −0.52 |
All the compounds at 100 μM significantly reduced the viability of PC-3 and MCF-7 cells (p < 0.001).66