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. 2019 Sep 2;9(47):27510–27540. doi: 10.1039/c9ra04917g

Evaluation of the cytotoxicity and log IC50 values (μM) of chalcone compounds and docetaxel (reference chemotherapeutic drug) on two cancer cell linesa.

Compound MCF-7 log IC50 (μM) PC-3 log IC50 (μM)
D1 2.12 1.54
37a 1.89 1.67
37b 1.15 1.24
37c 5.01 6.31
37d 5.79 1.81
37e 0.42 0.67
37d 2.30 2.47
37f 4.43 6.11
37g 2.55 2.57
37h 6.28 6.30
37i −0.21 0.92
Docetaxel (reference drug) −0.52 −0.52
a

All the compounds at 100 μM significantly reduced the viability of PC-3 and MCF-7 cells (p < 0.001).66